Perylenequinone Natural Products: Enantioselective Synthesis of the Oxidized Pentacyclic Core
نویسندگان
چکیده
منابع مشابه
Enantioselective assembly of the benzo[d]xanthene tetracyclic core of anti-influenza active natural products.
A combination of an enantioselective conjugate addition/trapping sequence and a ruthenium(iii)-catalyzed domino cyclization provides a concise access to benzo[d]xanthenes found in several anti-influenza active sesquiterpene natural products.
متن کاملPd-catalyzed enantioselective allylic substitution: new strategic options for the total synthesis of natural products.
The enantioselective version of palladium-catalyzed allylic substitution, sometimes referred to as AAA (asymmetric allylic alkylation), has emerged as a powerful synthetic tool.[1] Since the first report of a stoichiometric AAA reaction in the 1970s,[2] it took almost 20 years of research until effective catalytic systems based on chiral ligands were developed. The major challenge in conducting...
متن کاملEnantioselective synthesis of the [6,6] spiroketal core of reveromycin A.
[structure: see text] Reveromycin A (1) belongs to a family of microbial polyketides with unusual structural features and biological activities. The structure of 1 is composed of a [6,6] spiroketal core decorated with highly unsaturated side chains. As a prelude to the synthesis of 1, we present herein a short, efficient, and enantioselective synthesis of the C9-C21 fragment 5 (spiroketal core)...
متن کاملAryne acyl-alkylation in the general and convergent synthesis of benzannulated macrolactone natural products: an enantioselective synthesis of (-)-curvularin.
A general approach for the synthesis of benzannulated macrolactone natural products utilizing an aryne acyl-alkylation reaction is described. Toward this end, the total syntheses of the natural products (-)-curvularin, curvulin, and (-)-diplodialide C are reported. Furthermore, the aryne insertion technology has enabled the rapid conversion of simple diplodialide natural products to curvularin,...
متن کاملNatural Products Synthesis
Rhizopodin (1, Scheme 1) is an architecturally unique polyketide macrolide that was originally isolated from the myxobacterium Myxococcus stipitatus by the groups of Hçfle and Reichenbach. It shows potent antifungal and antiproliferative cytotoxicity against a range of tumor cell lines with IC50 values in the low nanomolar range. [1] On a molecular level, 1 disrupts the cytoskeleton of actin by...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Organic Chemistry
سال: 2009
ISSN: 0022-3263,1520-6904
DOI: 10.1021/jo9013832